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Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Andrew P. Landstrom, Noah Weisleder, Karin B. Batalden, J. Martijn Bos, David J. Tester, Steve R. Ommen, Xander H.T. Wehrens, William C. Claycomb, Jae-Kyun Ko, Moonsun Hwang, Zui Pan, Jianjie Ma, Mich

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2007

K + C HANNEL S TRUCTURE -A CTIVITY R ELATIONSHIPS AND M ECHANISMS OF D RUG -I NDUCED QT P ROLONGATION

Clancy, Colleen E., Kurokawa, Junko, Tateyama, Michihiro, Wehrens, Xander H.T., Kass, Robert S.

Journal:

Annual Review of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 637 KB

english, 2003

Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice

Respress, Jonathan L., Gershovich, Pavel M., Wang, Tiannan, Reynolds, Julia O., Skapura, Darlene G., Sutton, Jeffrey P., Miyake, Christina Y., Wehrens, Xander H.T.

Journal:

International Journal of Cardiology

Année:

2014

Langue:

english

Fichier:

PDF, 980 KB

english, 2014

The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Yuejin, Rasmussen, Tyler P., Koval, Olha M, Joiner, Mei-ling A., Hall, Duane D., Chen, Biyi, Luczak, Elizabeth D., Wang, Qiongling, Rokita, Adam G., Wehrens, Xander H.T., Song, Long-Sheng, Anderso

Journal:

Nature Communications

Année:

2015

Langue:

english

Fichier:

PDF, 2.88 MB

english, 2015

Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Yuejin, Rasmussen, Tyler P., Koval, Olha M., Joiner, Mei-ling A., Hall, Duane D., Chen, Biyi, Luczak, Elizabeth D., Wang, Qiongling, Rokita, Adam G., Wehrens, Xander H. T., Song, Long-Sheng, Ander

Journal:

Nature Communications

Année:

2015

Langue:

english

Fichier:

PDF, 258 KB

english, 2015

Oxidized CaMKII (Ca 2+ /Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy

Wang, Qiongling, Quick, Ann P., Cao, Shuyi, Reynolds, Julia, Chiang, David Y., Beavers, David, Li, Na, Wang, Guoliang, Rodney, George G., Anderson, Mark E., Wehrens, Xander H.T.

Journal:

Circulation Arrhythmia and Electrophysiology

Année:

2018

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2018

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

Pang, Paul D., Alsina, Katherina M., Cao, Shuyi, Koushik, Amrita B., Wehrens, Xander H.T., Cooper, Thomas A.

Journal:

Journal of the American Heart Association

Année:

2018

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2018

A Novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating

Xander H.T. Wehrens, Tom Rossenbacker, Roselie J. Jongbloed, Marc Gewillig, Hein Heidbüchel, Pieter A. Doevendans, Marc A. Vos, Hein J.J. Wellens, Robert S. Kass

Journal:

Human Mutation

Année:

2003

Langue:

english

Fichier:

PDF, 327 KB

english, 2003

Especially Polymorphonuclear Leukocytes, but also Monomorphonuclear Leukocytes, Roll Spontaneously in Venules of Intact Rat Skin: Involvement of E-Selectin

oude Egbrink, Mirjam G.A., Janssen, Gijsbertus H.G.W., Ookawa, Keiko, Slaaf, Dick W., Reneman, Robert S., Wehrens, Xander H.T., Maaijwee, Kristel J.M., Ohshima, Norio, Struijker Boudier, Harry A.J., T

Journal:

The Journal of Investigative Dermatology

Année:

2002

Langue:

english

Fichier:

PDF, 110 KB

english, 2002

Ryanodine receptors as pharmacological targets for heart disease

Marco SANTONASTASI, Xander H T WEHRENS

Journal:

Acta Pharmacologica Sinica

Année:

2007

Langue:

english

Fichier:

PDF, 565 KB

english, 2007

Novel therapeutic approaches for heart failure by normalizing calcium cycling

Wehrens, Xander H. T., Marks, Andrew R.

Journal:

Nature Reviews Drug Discovery

Année:

2004

Langue:

english

Fichier:

PDF, 386 KB

english, 2004

Stress synchronizes calcium release and promotes SR calcium leak

Wei Wang, Xander H. T. Wehrens

Journal:

The Journal of Physiology

Année:

2010

Langue:

english

Fichier:

PDF, 56 KB

english, 2010

Cardiac Ryanodine Receptor Function and Regulation in Heart Disease

STEPHAN E. LEHNART, XANDER H. T. WEHRENS, ALEXANDER KUSHNIR, ANDREW R. MARKS

Journal:

Annals of the New York Academy of Sciences

Année:

2004

Fichier:

PDF, 6.88 MB

2004

Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy

XANDER H.T. WEHRENS, STEPHAN E. LEHNART, ANDREW R. MARKS

Journal:

Annals of the New York Academy of Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 341 KB

english, 2005

Ryanodine Receptor Phosphorylation, Calcium/Calmodulin-Dependent Protein Kinase II, and Life-Threatening Ventricular Arrhythmias

Mark D. McCauley, Xander H.T. Wehrens

Journal:

Trends in Cardiovascular Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 181 KB

english, 2011

Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation

Dobromir Dobrev, Xander H.T. Wehrens

Journal:

Trends in Cardiovascular Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 243 KB

english, 2010

Altered function and regulation of cardiac ryanodine receptors in cardiac disease

Xander H.T Wehrens, Andrew R Marks

Journal:

Trends in Biochemical Sciences

Année:

2003

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2003

Usefulness of sinus tachycardia and ST-segment elevation in V5 to identify impending left ventricular free wall rupture in inferior wall myocardial infarction

Xander H.T Wehrens, Pieter A Doevendans, Jos W.M.G Widdershoven, Willem R.M Dassen, Kees Prenger, Hein J.J Wellens, Anton P.M Gorgels

Journal:

The American Journal of Cardiology

Année:

2001

Langue:

english

Fichier:

PDF, 348 KB

english, 2001

Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: A complex relationship

Sameer Ather, Wenyaw Chan, Annirudha Chillar, David Aguilar, Allison M. Pritchett, Kumudha Ramasubbu, Xander H.T. Wehrens, Anita Deswal, Biykem Bozkurt

Journal:

American Heart Journal

Année:

2011

Langue:

english

Fichier:

PDF, 306 KB

english, 2011

Calstabin deficiency, ryanodine receptors, and sudden cardiac death

Stephan E. Lehnart, Xander H.T. Wehrens, Andrew R. Marks

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 3.44 MB

english, 2004

Calcium/ Calmodulin Dependent Kinase Type II (CaMKIIδ) Phosphorylation of the Cardiac Ryanodine Receptor Is Crucial for the Development of Heart Failure

Jonathan L. Respress, Ralph J. van Oort, Angela C. de Almeida, Na Li, Natale Rolim, Ulrik Wisloff, Xander H.T. Wehrens

Journal:

Journal of Cardiac Failure

Année:

2011

Langue:

english

Fichier:

PDF, 59 KB

english, 2011

Ca2+/Calmodulin Dependent Protein Kinase II Phosphorylation of RyR2 Alters the Force-Frequency Relationship in Mice

Mark D. McCauley, Tiannan Wang, Sameer Ather, Na Li, Biykem Bozkurt, Xander Wehrens

Journal:

Journal of Cardiac Failure

Année:

2011

Langue:

english

Fichier:

PDF, 155 KB

english, 2011

Lack of Association of Changes in BNP with Cardiorenal Syndrome during Treatment of Acute Decompensated Heart Failure

Sameer Ather, Mark D. McCauley, Amandeep Dhaliwal, Anita Deswal, Wenyaw Chan, David Aguilar, Allison M. Pritchett, Kumudha Ramasubbu, Xander H.T. Wehrens, Biykem Bozkurt

Journal:

Journal of Cardiac Failure

Année:

2011

Langue:

english

Fichier:

PDF, 66 KB

english, 2011

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, S.-L. Catherine Jin, Marco Conti, Andrew R. Marks

Journal:

Cell

Année:

2005

Langue:

english

Fichier:

PDF, 568 KB

english, 2005

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, S.-L. Catherine Jin, Marco Conti, Andrew R. Marks

Journal:

Cell

Année:

2005

Langue:

english

Fichier:

PDF, 95 KB

english, 2005

Cardiac rupture complicating myocardial infarction

Xander H.T. Wehrens, Pieter A. Doevendans

Journal:

International Journal of Cardiology

Année:

2004

Langue:

english

Fichier:

PDF, 240 KB

english, 2004

Mutation-specific effects of lidocaine in Brugada syndrome

Colleen E. Clancy, Xander H.T. Wehrens

Journal:

International Journal of Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 206 KB

english, 2007

Digoxin treatment in heart failure — Unveiling risk by cluster analysis of DIG data

Sameer Ather, Leif E. Peterson, Vijay G. Divakaran, Anita Deswal, Kumudha Ramasubbu, Irakli Giorgberidze, Alvin Blaustein, Xander H.T. Wehrens, Douglas L. Mann, Biykem Bozkurt

Journal:

International Journal of Cardiology

Année:

2011

Langue:

english

Fichier:

PDF, 342 KB

english, 2011

Abnormal ryanodine receptor calcium release induces atrial fibrillation

Subeena Sood, Marco Santonastasi, Haiyun Cheng, Xander H. Wehrens

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2007

Langue:

english

Fichier:

PDF, 52 KB

english, 2007

Alternative splicing: A key mechanism for ankyrin-B functional diversity?

Ralph J. van Oort, Julio Altamirano, W.J. Lederer, Xander H.T. Wehrens

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2008

Langue:

english

Fichier:

PDF, 358 KB

english, 2008

A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty

Xander H.T. Wehrens, Pieter A. Doevendans, Ton J. Oude Ophuis, Hein J.J. Wellens

Journal:

American Heart Journal

Année:

2000

Langue:

english

Fichier:

PDF, 4.53 MB

english, 2000

Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis

Xander H.T. Wehrens, Pieter A. Doevendans, Jan Melle van Dantzig, Gabriel Snoep, Hein J. Wellens

Journal:

American Heart Journal

Année:

1996

Langue:

english

Fichier:

PDF, 1.73 MB

english, 1996

FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

Xander H.T. Wehrens, Stephan E. Lehnart, Fannie Huang, John A. Vest, Steven R. Reiken, Peter J. Mohler, Jie Sun, Silvia Guatimosim, Long-Sheng Song, Nora Rosemblit, Jeanine M. D'Armiento, Carlo Napoli

Journal:

Cell

Année:

2003

Langue:

english

Fichier:

PDF, 729 KB

english, 2003

Publications from extracurricular research

Xander HT Wehrens, Tim Leiner

Journal:

The Lancet

Année:

2001

Langue:

english

Fichier:

PDF, 47 KB

english, 2001

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Yiming Wu, Elizabeth D. Luczak, Eun-Jeong Lee, Carlos Hidalgo, Jinying Yang, Zhan Gao, Jingdong Li, Xander H.T. Wehrens, Henk Granzier, Mark E. Anderson

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2012

Langue:

english

Fichier:

PDF, 932 KB

english, 2012

Nanoscale Organization of Junctophilin-2 and Ryanodine Receptors within Peripheral Couplings of Rat Ventricular Cardiomyocytes

Jayasinghe, Isuru D., Baddeley, David, Kong, Cherrie H.T., Wehrens, Xander H.T., Cannell, Mark B., Soeller, Christian

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 568 KB

english, 2012

Mechanisms of heart failure: emerging molecular targets

Xander H.T. Wehrens, Andrew R. Marks

Journal:

Drug Discovery Today: Disease Mechanisms

Année:

2004

Langue:

english

Fichier:

PDF, 265 KB

english, 2004

Computational and experimental models of Ca2+-dependent arrhythmias

Eric A. Sobie, Xander H.T. Wehrens

Journal:

Drug Discovery Today: Disease Models

Année:

2009

Langue:

english

Fichier:

PDF, 111 KB

english, 2009

Ryanodine receptors as drug targets for heart failure and cardiac arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Andrew R. Marks

Journal:

Drug Discovery Today: Therapeutic Strategies

Année:

2005

Langue:

english

Fichier:

PDF, 451 KB

english, 2005

Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction

Sameer Ather, Wenyaw Chan, Biykem Bozkurt, David Aguilar, Kumudha Ramasubbu, Amit A. Zachariah, Xander H.T. Wehrens, Anita Deswal

Journal:

Journal of the American College of Cardiology

Année:

2012

Langue:

english

Fichier:

PDF, 700 KB

english, 2012

Chronic Exercise

Wehrens, Xander H.T., Chiang, David Y., Li, Na

Journal:

Journal of the American College of Cardiology

Année:

2013

Langue:

english

Fichier:

PDF, 114 KB

english, 2013

INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

Wehrens, Xander H.T., Lehnart, Stephan E., Marks, Andrew R.

Journal:

Annual Review of Physiology

Année:

2005

Langue:

english

Fichier:

PDF, 427 KB

english, 2005

Alterations in ryanodine receptors and related proteins in heart failure

Ather, Sameer, Respress, Jonathan L., Li, Na, Wehrens, Xander H.T.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2013

Langue:

english

Fichier:

PDF, 732 KB

english, 2013

[Developments in Cardiovascular Medicine] Ryanodine Receptors Volume 254 || Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels

Wehrens, Xander H. T., Marks, Andrew R.

Année:

2005

Langue:

english

Fichier:

PDF, 823 KB

english, 2005

Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy

Ather, Sameer, Wang, Wei, Wang, Qiongling, Li, Na, Anderson, Mark E., Wehrens, Xander H.T.

Journal:

Heart Rhythm

Année:

2013

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2013

Sudden Unexplained Death Caused by Cardiac Ryanodine Receptor (RyR2) Mutations

Wehrens, Xander H.T., Marks, Andrew R.

Journal:

Mayo Clinic Proceedings

Année:

2004

Langue:

english

Fichier:

PDF, 96 KB

english, 2004

Nanoscale Changes in the Organisation of Junctional Proteins in JPH2 Transgenic Mice

Munro, Michelle, Wang, Wei, Baddeley, David, Wehrens, Xander, Soeller, Christian

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 84 KB

english, 2014

The junctophilin family of proteins: from bench to bedside

Landstrom, Andrew P., Beavers, David L., Wehrens, Xander H.T.

Journal:

Trends in Molecular Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 809 KB

english, 2014

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome

DeGrande, Sean, Nixon, Derek, Koval, Olha, Curran, Jerald W., Wright, Patrick, Wang, Qiongling, Kashef, Farshid, Chiang, David, Li, Na, Wehrens, Xander H.T., Anderson, Mark E., Hund, Thomas J., Mohler

Journal:

Heart Rhythm

Année:

2012

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2012

Extinguishing intracellular calcium leak: A promising antiarrhythmic approach

Li, Na, Wehrens, Xander H.T.

Journal:

Heart Rhythm

Année:

2013

Langue:

english

Fichier:

PDF, 62 KB

english, 2013